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History of HIV Treatment And Advances
Human Immunodeficiency Virus (HIV) has proved to be a monster health problem in the world as millions of individuals are getting infected across the globe. The presence of HIV is a permanent disease despite the advancement in the antiretroviral therapy (ART) in several decades. However, the future of HIV treatment is not so gloomy since new practice, technology, and medical breakthroughs provide a chance to discover a more effective, available, and sustainable treatment. The HIV care landscape is evolving, and a growing array of possibilities surrounding both gene therapies and long-acting injectable drugs in particular hold out the hope of improved outcomes and even a cure.
The Recent HIV Treatment is the use of Antiretroviral Therapy (ART).
Since the advent of the antiretroviral therapy (ART) in 1990s, there has been no more powerful weapon used in managing HIV in comparison with antiretroviral therapy. ART can assist by preventing HIV replication in the body and not only prolongs the lives of people living with the disease but also leads a healthier life. Though ART is effective in the management of the virus, the medication does not treat HIV and therefore necessitates lifetime treatment. The current model of the ART suggests a combination of medications that target different phases of the HIV life cycle and is destined to inhibit the development of resistance as well as render the virus suppressed. However, the need to take prescriptions and potential side effects are also rather significant issues of the patients.
A new age of HIV Treatment: Long-Acting Injectables Therapy
Some of the most brutal advancements that are related to HIV treatment include the long acting injections. These treatments are to make the life of the people living with HIV more convenient by reducing the frequency of dosing. The remedy may present itself in the form of an injection every four to eight weeks as compared to pills that should be consumed daily. The drugs are long acting to the ART and the next-generation ones like cabotegravir and rilpivirine have already shown potential in the clinical stages and would most likely be a set commodity in the management of HIV. Such innovation will not only ensure that the patient takes medication, but it will also remove the everyday stigma of medications.
A Cure To HIV: Gene Therapy
The coming up of gene therapy as one of the innovative approaches of HIV cure has shown as well. Possible methods of curing HIV are ways that are currently being researched that could either correct the functioning of the immune system or that of the virus such that it could be killed or placed in an inactive state. The other alluring route hears like using the CRISPR-Cas9 gene-editing technology to cure it and cut the stored HIV DNA in the genome of the host. The other technique entails the engineering of the immune cells who then contain T-cells to become immune against HIV. Even though the idea of HIV cure using gene therapy has not been successful yet, there is hope of achieving the HIV cure becoming a reality owing to increased research and clinical trials.
A Push to End HIV-Stem Cell Therapy
Possibilities in clinical use were also exhibited in the elimination of HIV through the use of stem cell therapy. One of the highly discussed cases of stem cell use in treating HIV is the case of the Berlin patient since the patient was leukemia treated and thereby performed stem cell transplant. The transplant rendered the patient functional HIV cure with a blood level which could not detect the presence of the virus. Having HIV curable at a wider level is now under researches in regards to the possibility of stem cell transplants or the genome edited stem cells options. However, the practice is not risk free because stem cells transplants are complex and linked to harsh medical challenges.
The HIV Treatment Immune Modulatory Simple Application
A thriving research area in the treatment of HIV is in immune modulation. Scientists strive to create strategies of managing or eliminating HIV through enhancement of the innate immunity of the body. Some of them include boosting the immunity system to detect and destroy HIV-infected cells. Immunotherapeutic vaccines known as monoclonal antibodies are being prepared that will target certain proteins in the HIV-infected cell and trigger the protectors to strike against the virus. These therapies, though still experimental, have the potential of being of great benefit to individuals with HIV as far as long survival is concerned.
Preventative and curative course Therapeutic Vaccines: Therapeutic Vaccines are used as potential vaccines to protect populations against the infectious disease.
One of the new methods of HIV treatment is a therapeutic vaccine. Unlike the conventional vaccines that prevent infection, therapeutic vaccines aim to boost immune system of persons already infected by HIV. These vaccines would limit the spread of the virus by causing immune response in the body and thus prevents the lifelong reliance on ART. Some have begun clinical trials and are returning promising early results. Therapeutic vaccines, in the event of successful establishment, would be characterized by not only just the advantage of bringing great values to the lives of the individuals living with HIV but also enjoy the benefit of reducing the reliance on the daily supply of medications and even the possibility of the discovery of the cure.
Individualized Treatment of HIV: Precision Medicine
The personalization of treatment, otherwise known as precision medicine by adapting it to the genetic profile of a specific patient is, likewise, becoming topical in the treatment of HIV. Examining the genetics of an individual, the physicians will learn what methods will help him more and those which result in the appearance of the undesired side effects. To illustrate, the pharmacogenetic test could be used to determine the most effective antiretroviral drugs in a particular person when compared to individual body response to the medications. In addition, precision medicine can identify genetic variants that may predispose one to being infected by HIV or to immune responses towards the virus.
Interventions HIV Microbiome-Based
Microbiome The humankind- inhabiting, 3-trillion-bacteria, virus and fungi collection, also known as human microbiome, is the focal point of human immunity. Nevertheless, current research shows that microbiome is involved in the decision about how individuals would react to HIV infection and the process of its progression. The researchers have identified that healthy microbiome is beneficial in the prevention of the generation of HIV but manipulating the gut bacteria balance would lead to high viral load and inflammation. An area where microbiome is being used as potential adjunct in HIV treatment involves the use of microbiome –related treatment, such as probiotics, prebiotics and fecal transplants. The aim of these approaches is to restore the homeostasis of the microbiome and increase the level of immune status in HIV patients.
One, A New Class of Therapy Broadly Neutralizing Antibodies
The recently developed forms of therapeutics have also shown potentially useful activity against HIV, the broadly neutralizing antibodies (bNAbs). Unlike traditional antibodies which respond to specific strains of the virus, bNAbs can also avert the wide assortments of infection of HIV through physical attachment to significant sites of the envelope protein of the virus. These antibodies were found to reduce viral load and also potentially prevent new infection on the high risk subjects too. A clinical roadmap remains to determine how best to employ bNAbs in an ART combination and currently there is hope that these antibodies will eventually become an effective tool in the HIV treatment and prevention toolkit.
HIV Cure Research: Finding a working HIV Cure
Although there is yet to be a proficient method of treatment of HIV, there are scientists who develop the concept of functional cure. A functional-cure does not necessarily mean total elimination of the virus but ensures it remains dormant to enable infection of the virus by the bodies immune system such that the immune system can ultimately take over HIV without ART. This includes an intersection of combination of gene therapy with immune modulation with other aggressive therapy is possible. The hope is that through functional cure there would be a permanent solution to the population living with HIV since they would have an opportunity to live without necessarily taking medication daily and facing the risk of being advanced to the extent of being capable of spreading the virus to other individuals.
World Health Map And HIV Treatment
The HIV treatment is at its developmental pace, and clinical access is at the discussing stage because of its topical character. In most parts of the world, especially the low and middle-income countries, financial, logistic and social restrictions to the availability of both ART and HIV care are very prevalent. Such impediments need to be addressed as they represent the most important step toward making the latest developments in the treatment available to all individuals with HIV regardless of whether they live in a developed or underdeveloped region and have high or low socioeconomic status. Even such international programs like the UNAIDS Fast-Track Strategy or the Global Fund to Fight AIDS, Tuberculosis, and Malaria are yet to increase chances of HIV treatment and care worldwide.
The Stigma Of HIV Treatment And Progress
Stigma represents one of the most noticeable barriers to the HIV treatment and prevention. HIV patients are exposed to stigma and fear of being avoided by society which may or may not act as a motivator to seek any medical care or treatment protocols. Stigma should be minimized in order to improve treatment and care through the means of education, awareness, and policy implementation processes to make sure that individuals have no reservations or fear about receiving treatment because of stigma. Support, advocacy and health campaigns among the neighborhoods and mass media are significant community activities to win the battle against the stigma of HIV and to realize a quality of life of HIV infected persons.
What To Get Expectant In The Future 10 years With HIV Prevention And Treatment
The curing facet of the HIV disease is promising to be brighter in future since research has not come to an end in finding better and affordable modes of curing it. It is likely that within the following decade, innovation in long-acting therapies, gene and vaccine development will be observed. Precision medicine will allow more personal care, and the immunomodulation will enhance the reaction of the body in the virus fight without the chronic ART. As the world society makes an effort to eliminate HIV, the targeted goal of one day achieving a cure is fast becoming true.
Decision: Anticipation of an HIV- free world
The treatment of HIV is evolving with medical, technological and international health campaigns and this gives hope to individuals living with the disease. We must admit that the work of the scientific community since the past few years is a testimony to the struggle towards the improved future of people with HIV despite the long way to go. Based on further studies, easier access to treatment and the reduction of the stigma, the stigma-free and HIV-free world is becoming to be real, which is closer.